• About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News
Friday, March 31, 2023
  • Login
National Age
  • Home
  • India
    • National
    • State News
  • World
  • Education
  • Lifestyle
    • Health & Fitness
    • Fashion
    • Travel
    • Food
  • Business
  • Tech
    • App News
    • Gadgets
  • Entertainment
  • Auto
  • Sports
  • Others
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
No Result
View All Result
  • Home
  • India
    • National
    • State News
  • World
  • Education
  • Lifestyle
    • Health & Fitness
    • Fashion
    • Travel
    • Food
  • Business
  • Tech
    • App News
    • Gadgets
  • Entertainment
  • Auto
  • Sports
  • Others
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
No Result
View All Result
National Age
No Result
View All Result
Home Lifestyle Health & Fitness

Treatment of progressive neurological, neuromuscular disorder gets a shot in the arm  

National Age by National Age
February 10, 2022
in Health & Fitness, Science
0
Treatment of progressive neurological, neuromuscular disorder gets a shot in the arm  
Share on FacebookShare on Twitter

New Delhi, Feb 10: A new treatment could soon be in the offing for Fragile X-associated tremor/ataxia syndrome (FXTAS). Currently, management of the disorder is limited to symptomatic treatment of psychiatric and behavioral problems. 

Patients with the disease, a progressive neurological and neuromuscular disorder, could show several symptoms such as problems in balancing during walking, shaking of hands when grabbing things, memory loss, autonomic dysfunction, cognitive decline, seizure, and Parkinsonism. It affects 1 in 4,000 males and 1in 6,000 to 8,000 females worldwide. It usually begins at the age of 58 to 60 years. 

It is caused by a specific type of mutation in the DNA sequence of a gene called fragile X mental retardation 1 (FMR1). The mutation is named CGG trinucleotide repeat. The number of trinucleotides repeats in FXTAS patients is more than 200 times compared to healthy persons, where it is 55 times. This excess trinucleotide repeats cause cytotoxicity in neuronal cells leading to brain cells degeneration. 

Read ThisAlso

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

March 20, 2023
Do rare Diseases account for the economic burden on India?

Do rare Diseases account for the economic burden on India?

March 18, 2023

A team led by Dr. Amit Kumar, Associate Professor and Head, Department of Biosciences and Biomedical Engineering at Indian Institute of Technology (IIT)- Indore has found three chemical compounds that significantly reduce the trinucleotide repeats RNA associated neuronal cells cytotoxicity and restored normal cell viability, in preliminary studies.

The researchers identified the compounds from a library of about 25 lakh small molecules maintained by the National Cancer Institute (NCI), United States of America. This study was conducted in three different steps: shape and chemical-based virtual screening; biophysical analysis of the lead compounds with target RNA; and analysis of the potency of lead molecules using diseased cellular models. 

The lead compounds were tested in both developed cellular models of FXTAS and cell lines isolated from a patient suffering from the disease. Three compounds at the end were found to be selective and specific against CGG repeat RNA. 

Speaking to India Science Wire, Dr. Kumar said, “CGG trinucleotide repeats expansion is involved in the pathogenesis of more than 15 different neurological diseases. We hope our finding would help in developing therapeutics for other diseases too”. 

The study team included Arun Kumar Verma, Eshan Khan, and Subodh Kumar Mishra. They have published a report of their work in the science journal Molecular Neurobiology, Springer. (India Science Wire)

National Age

See author's posts

Tags: braincellDNAFragile X-associated tremor/ataxia syndromeFXTASgeneIndian Institute of Technologymemory lossmutationneuronalParkinsonismpsychiatricscreening; biophysicalseizuresequencetreatment
Share9Tweet6Share2SendShareSend
Previous Post

Dr. Dame Munni Irone’s Best Seller Book “Get Balance” awakens intellectual values among people

Next Post

Top six youngest real estate entrepreneurs of Noida

National Age

National Age

Related Posts

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services
Health & Fitness

Japan-based Toyota Tsusho Corporation and Tokai Corp Partner to Launch Valabhi Hospital Services

March 20, 2023
Do rare Diseases account for the economic burden on India?
Health & Fitness

Do rare Diseases account for the economic burden on India?

March 18, 2023
zPlus.care for all your healthcare needs
Health & Fitness

zPlus.care for all your healthcare needs

March 17, 2023
YOGA – A blessing for feminine fitness by Heena Rajgor
Health & Fitness

YOGA – A blessing for feminine fitness by Heena Rajgor

March 9, 2023
Protect your Hair this Holi with these Pro tips by Danish Batra MD of Hair Masters Luxury Salon
Health & Fitness

Protect your Hair this Holi with these Pro tips by Danish Batra, MD of Hair Masters Luxury Salon

March 4, 2023
Narayana Health’s multi-location campaigns emphasize on Awareness and honour the spirit of Cancer Survivors
Health & Fitness

Narayana Health’s multi-location campaigns emphasize on Awareness and honour the spirit of Cancer Survivors

March 1, 2023
Next Post
Top six youngest real estate entrepreneurs of Noida

Top six youngest real estate entrepreneurs of Noida

Zee5 Celebrates 4th Anniversary with India Ka Binge-A-Thon

Zee5 Celebrates 4th Anniversary with India Ka Binge-A-Thon

Dinesh Karthik & Dipika Pallikal Credits NeoLacta’s 100% Human Milk for Good Health of Twins

Dinesh Karthik & Dipika Pallikal Credits NeoLacta’s 100% Human Milk for Good Health of Twins

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

  • Trending
  • Comments
  • Latest
Pro Cricket Championship Trophy (PCCT) announced the schedule of their selection trials and matches today

Pro Cricket Championship Trophy (PCCT) announced the schedule of their selection trials and matches today

May 26, 2022
Now our E-store India has become an international company

Now our E-store India has become an international company

November 1, 2022
Rotary announces: 20th Global Poster Painting Competition

Rotary announces: 20th Global Poster Painting Competition

June 8, 2022
Influencerquipo presents Most Confident plus Size Influencer of the year- Jaanvi

Influencerquipo presents Most Confident plus Size Influencer of the year- Jaanvi

August 11, 2021
Pro Cricket Championship Trophy (PCCT) announced the schedule of their selection trials and matches today

Pro Cricket Championship Trophy (PCCT) announced the schedule of their selection trials and matches today

14
MPF Investments are mainly aimed at companies in the Indian Market

MPF Investments are mainly aimed at companies in the Indian Market

4

TECNO launches SPARK Power 2 Air: The new Power Play Entertainment device

2

PrivateCourt is all set to revolutionize the concept of Online Dispute Resolution

1
Founder of Jade Homes Arnab Ghosh made home construction easy and in your control

Founder of Jade Homes Arnab Ghosh made home construction easy and in your control

March 30, 2023
Studywoo launch “One stop solution for students’ education needs”

Studywoo launch “One stop solution for students’ education needs”

March 30, 2023
Elante Group Launches USD 5 mn premium housing project in Gurugram

Elante Group Launches USD 5 mn premium housing project in Gurugram

March 30, 2023
Kingston Technology Tops List of Supplier Channel SSD Shipments in 2022

Kingston Technology Tops List of Supplier Channel SSD Shipments in 2022

March 29, 2023

Recent News

Founder of Jade Homes Arnab Ghosh made home construction easy and in your control

Founder of Jade Homes Arnab Ghosh made home construction easy and in your control

March 30, 2023
Studywoo launch “One stop solution for students’ education needs”

Studywoo launch “One stop solution for students’ education needs”

March 30, 2023
Elante Group Launches USD 5 mn premium housing project in Gurugram

Elante Group Launches USD 5 mn premium housing project in Gurugram

March 30, 2023
Kingston Technology Tops List of Supplier Channel SSD Shipments in 2022

Kingston Technology Tops List of Supplier Channel SSD Shipments in 2022

March 29, 2023

www.nationalage.com, digital news and story platform bring you the news, articles, stories, and opinions on the latest happenings worldwide covering various sectors like nation, politics, and governance, social sector, review, foreign affairs, defence and security, latest review, lifestyle, entertainment, sports, technology, auto sectors, education, business and start-ups updates, Agriculture, Science, finance, money, food, and culture, etc.

If you have any query regarding Site, Advertisement, and any other issue, please feel free to contact at [email protected]

Follow Us

Browse by Category

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion
  • Finance/Money
  • Food
  • Gadgets
  • Health & Fitness
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • World
Founder of Jade Homes Arnab Ghosh made home construction easy and in your control

Founder of Jade Homes Arnab Ghosh made home construction easy and in your control

March 30, 2023
Studywoo launch “One stop solution for students’ education needs”

Studywoo launch “One stop solution for students’ education needs”

March 30, 2023
Elante Group Launches USD 5 mn premium housing project in Gurugram

Elante Group Launches USD 5 mn premium housing project in Gurugram

March 30, 2023
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News

Copyright © 2021 National Age

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

Copyright © 2021 National Age

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In