• About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News
Saturday, May 31, 2025
  • Login
National Age
  • Home
  • India
    • National
    • State News
  • World
  • Education
  • Lifestyle
    • Health & Fitness
    • Fashion
    • Travel
    • Food
  • Business
  • Tech
    • App News
    • Gadgets
  • Entertainment
  • Auto
  • Sports
  • Others
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
No Result
View All Result
  • Home
  • India
    • National
    • State News
  • World
  • Education
  • Lifestyle
    • Health & Fitness
    • Fashion
    • Travel
    • Food
  • Business
  • Tech
    • App News
    • Gadgets
  • Entertainment
  • Auto
  • Sports
  • Others
    • Agriculture
    • Science
    • Astrology
    • Finance/Money
    • Press Release
No Result
View All Result
National Age
No Result
View All Result
Home Lifestyle Health & Fitness

Researchers reveal how excess sugar causes fatty liver

National Age by National Age
June 18, 2021
in Health & Fitness
0
Researchers reveal how excess sugar causes fatty liver

Dr.Prosenjit Mondal and P. Vineeth Daniel(L to R)

Share on FacebookShare on Twitter

New Delhi: In a new study conducted by the researchers at Indian Institute of Technology (IIT), Mandi has conclusively shown that excessive sugar intake leads to a fatty liver. This could offer an incentive for reducing sugar intake to stop non-alcoholic fatty liver disease (NAFLD) in its early stages. The unravelling of the molecular link between sugar and fat accumulation in liver is key to developing therapeutics for the disease, researchers said.

A team of researchers from IIT Mandi, led by Dr Prosenjit Mondal, Associate Professor, School of Basic Sciences, has used complementary experimental approaches to establish the underlying biochemical relationship between the consumption of excessive sugar and the development of ‘fatty liver’, medically known as Non-Alcoholic Fatty Liver Disease (NAFLD). This research comes at a time in which the Government of India has included NAFLD in the National Programme for Prevention & Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS).

NAFLD is a medical condition in which excess fat deposits in the liver. The disease starts silently, with no overt symptoms for as much as two decades. If left untreated, the excess fat can irritate the liver cells, resulting in scarring of the liver (cirrhosis), and in advanced cases, can even lead to liver cancer. The treatment of advanced stages of NAFLD is difficult.

Read ThisAlso

Combining NDT and DMI: A Comprehensive Approach to Developmental Delay

Combining NDT and DMI: A Comprehensive Approach to Developmental Delay

May 28, 2025
As COVID-19 Cases Resurface, Pravek Kalp Promotes Ayurvedic Immunity and Heart Health with Ashwagandha and Arjuna Capsules

As COVID-19 Cases Resurface, Pravek Kalp Promotes Ayurvedic Immunity and Heart Health with Ashwagandha and Arjuna Capsules

May 27, 2025

Dr Prosenjit Mondal said, “The molecular mechanisms that increase hepatic DNL due to overconsumption of sugar have not been clear.” “Our goal was to unravel this mechanistic pathway between excessive sugar consumption and onset and development of fatty liver Through DNL”, he further added.

India is the first country in the world to identify the need for action on NAFLD and with good reason. The prevalence of NAFLD in India is about 9% to 32% of the population, with the state of Kerala alone having a prevalence of 49% and a staggering 60% prevalence among obese school-going children.

One of the causes for NAFLD is the over-consumption of sugar – both table sugar (sucrose) and other forms of carbohydrates. The consumption of excess sugar and carbohydrates causes the liver to convert them into fat in a process called hepatic De Novo Lipogenesis or DNL, which leads to fat accumulation in the liver.

Through a complementary experimental approach involving mice models, the IIT Mandi team has shown the hitherto unknown link between the carbohydrate-induced activation of a protein complex called NF-κB and increased DNL.

“Our data indicates that the sugar-mediated shuttling of hepatic NF-κB p65 reduces the levels of another protein, sorcin, which in turn activates liver DNL through a cascading biochemical pathway,” explained the lead scientist.

The research team has shown that drugs that can inhibit NF-κB can prevent sugar-induced hepatic fat accumulation. They have also shown that the knockdown of sorcin reduces the lipid-lowering ability of the NF-κB inhibitor.

This study shows that NAFLD can now be added to the repertoire of diseases that can be treated with drugs that block NF-κB. NF-κB also plays a role in other diseases that involve inflammation, such as cancer, Alzheimer’s disease, atherosclerosis, IBS, stroke, muscle wasting and infections, and scientists around the world are developing therapeutics that can block NF-κB, IIT Mandi Statement said.

This study has been published in the Journal of Biological Chemistry. The research paper has been co-authored by Dr Prosenjit Mondal along with his research scholars, Mr. Vineeth Daniel, Ms. Surbhi Dogra, Ms. Priya Rawat, Mr. Abhinav Choubey from IIT Mandi, in collaboration with Dr Mohan Kamthan and Ms. Aiysha Siddiq Khan from Jamia Hamdard Institute, New Delhi, along with Mr. Sangam Rajak from SGPGI, Lucknow. (India Science Wire)

Tags: Fatty LiverIIT MandiIndian Institute of TechnologyKeywords: Sugar IntakemolecularNAFLDNon-alcoholic fatty liver disease
Share6Tweet4Share1SendShareSend
Previous Post

Older adults are at higher risk of social isolation during COVID pandemic: Study

Next Post

Sara Chhipa, 10-year-old, Indian, World Record Holder felicitated by the Consulate General of India in Dubai, UAE

National Age

National Age

Related Posts

Combining NDT and DMI: A Comprehensive Approach to Developmental Delay
Health & Fitness

Combining NDT and DMI: A Comprehensive Approach to Developmental Delay

May 28, 2025
As COVID-19 Cases Resurface, Pravek Kalp Promotes Ayurvedic Immunity and Heart Health with Ashwagandha and Arjuna Capsules
Health & Fitness

As COVID-19 Cases Resurface, Pravek Kalp Promotes Ayurvedic Immunity and Heart Health with Ashwagandha and Arjuna Capsules

May 27, 2025
Global aesthetic thought leader shares innovations at milestone SIME 2025 event in Italy
Health & Fitness

Global aesthetic thought leader shares innovations at milestone SIME 2025 event in Italy

May 23, 2025
Aarogyaa Bharat: The Pune-Based Startup Revolutionizing Access to Medical Equipment Across India
Health & Fitness

Aarogyaa Bharat: The Pune-Based Startup Revolutionizing Access to Medical Equipment Across India

May 21, 2025
Invisalign Treatment Delivers Predictable Results for Adult Patients, Achieving Complete Space Closure in as Little as 8 Months
Health & Fitness

Invisalign Treatment Delivers Predictable Results for Adult Patients, Achieving Complete Space Closure in as Little as 8 Months

May 20, 2025
Dr. Vikas Sharma (LaghaV) – Winner of the 21st Century Emily Dickinson Award
Health & Fitness

Dr. Vikas Sharma (LaghaV) – Winner of the 21st Century Emily Dickinson Award

May 17, 2025
Next Post
Sara Chhipa 10-year-old Indian World Record Holder felicitated by the Consulate General of India in Dubai UAE

Sara Chhipa, 10-year-old, Indian, World Record Holder felicitated by the Consulate General of India in Dubai, UAE

TTK Prestige Ltd launches a new e-commerce enabled website for its second brand “JUDGE” in India 

TTK Prestige Ltd launches a new e-commerce enabled website for its second brand “JUDGE” in India 

Indian Pharmaceutical Company conducts Clinical Analysis for the Supplement to battle against Post COVID-19 difficulties

Indian Pharmaceutical Company conducts Clinical Analysis for the Supplement to battle against Post COVID-19 difficulties

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

  • Trending
  • Comments
  • Latest
Pro Cricket Championship Trophy (PCCT) announced the schedule of their selection trials and matches today

Pro Cricket Championship Trophy (PCCT) announced the schedule of their selection trials and matches today

May 26, 2022
Now our E-store India has become an international company

Now our E-store India has become an international company

November 1, 2022
Rotary announces: 20th Global Poster Painting Competition

Rotary announces: 20th Global Poster Painting Competition

June 8, 2022
On 27th & 28th December at Surat Marriott, Athwalines India’s premier fashion showcase Hi Life Exhibition is back

On 27th & 28th December at Surat Marriott, Athwalines India’s premier fashion showcase Hi Life Exhibition is back

December 26, 2023

Changa Video sharing app crosses 2 million on play store

0

World’s first DeepUV Air Sanitizer, launched by Indian startup Dokat Inc.

0

Japan’s tech start-ups bitgrit and Atrae rolls out professional ‘matching’ app in India offering jobs in India

0

Surat’s company invents – low-cost,high-end ventilator in support of the Aatmanirbhar Bharat Abhiyan

0
TCL Q6 Series: The Real Deal for Tech-Savvy TV Buyers This Year? (Yeah, We’re Looking Closely!)

TCL Q6 Series: The Real Deal for Tech-Savvy TV Buyers This Year? (Yeah, We’re Looking Closely!)

May 30, 2025
Hemant Suresh Avhad – Winner of the 21st Century Emily Dickinson Award

Hemant Suresh Avhad – Winner of the 21st Century Emily Dickinson Award

May 30, 2025
Chander Parkash Malhotra – Winner of the 21st Century Emily Dickinson Award

Chander Parkash Malhotra – Winner of the 21st Century Emily Dickinson Award

May 29, 2025
Rajarshi Choudhury – Winner of the 21st Century Emily Dickinson Award

Rajarshi Choudhury – Winner of the 21st Century Emily Dickinson Award

May 28, 2025

Recent News

TCL Q6 Series: The Real Deal for Tech-Savvy TV Buyers This Year? (Yeah, We’re Looking Closely!)

TCL Q6 Series: The Real Deal for Tech-Savvy TV Buyers This Year? (Yeah, We’re Looking Closely!)

May 30, 2025
Hemant Suresh Avhad – Winner of the 21st Century Emily Dickinson Award

Hemant Suresh Avhad – Winner of the 21st Century Emily Dickinson Award

May 30, 2025
Chander Parkash Malhotra – Winner of the 21st Century Emily Dickinson Award

Chander Parkash Malhotra – Winner of the 21st Century Emily Dickinson Award

May 29, 2025
Rajarshi Choudhury – Winner of the 21st Century Emily Dickinson Award

Rajarshi Choudhury – Winner of the 21st Century Emily Dickinson Award

May 28, 2025

www.nationalage.com, digital news and story platform bring you the news, articles, stories, and opinions on the latest happenings worldwide covering various sectors like nation, politics, and governance, social sector, review, foreign affairs, defence and security, latest review, lifestyle, entertainment, sports, technology, auto sectors, education, business and start-ups updates, Agriculture, Science, finance, money, food, and culture, etc.

If you have any query regarding Site, Advertisement, and any other issue, please feel free to contact at [email protected]

Follow Us

Browse by Category

  • Agriculture
  • App News
  • Astrology
  • Auto
  • Business
  • Education
  • Entertainment
  • Fashion
  • Finance/Money
  • Food
  • Gadgets
  • Health & Fitness
  • Lifestyle
  • National
  • Photography
  • Politics
  • Press Release
  • Religion
  • Science
  • Social Work
  • Sports
  • State News
  • Tech
  • Travel
  • Uncategorized
  • World
TCL Q6 Series: The Real Deal for Tech-Savvy TV Buyers This Year? (Yeah, We’re Looking Closely!)

TCL Q6 Series: The Real Deal for Tech-Savvy TV Buyers This Year? (Yeah, We’re Looking Closely!)

May 30, 2025
Hemant Suresh Avhad – Winner of the 21st Century Emily Dickinson Award

Hemant Suresh Avhad – Winner of the 21st Century Emily Dickinson Award

May 30, 2025
Chander Parkash Malhotra – Winner of the 21st Century Emily Dickinson Award

Chander Parkash Malhotra – Winner of the 21st Century Emily Dickinson Award

May 29, 2025
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Follow on Google News

Copyright © 2021 National Age

No Result
View All Result
  • About Us
  • Advertise
  • Contact Us
  • DMCA
  • Home
  • Privacy Policy

Copyright © 2021 National Age

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In